Selective C-N bond oxidation:: demethylation of N-methyl group in N-arylmethyl-N-methyl-α-amino esters utilizing N-iodosuccinimide (NIS)

被引：14

作者：

Katoh, Takahiro ^{[1
]}

Watanabe, Tsunefumi ^{[1
]}

Nishitani, Mitsuyoshi ^{[1
]}

Ozeki, Minoru ^{[1
]}

Kajimoto, Tetsuya ^{[1
]}

Node, Manabu ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Pharmaceut Mfg Chem, COE Program, Yamashina Ku, Kyoto 6078418, Japan

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 04期

关键词：

D O I：

10.1016/j.tetlet.2007.11.162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Demethylation of N-methyl group in N-methyl-N-arylmethyl-alpha-amino esters was accomplished by the oxidation of the amino group using the N-iodosuccinimide (NIS)/acetonitrile system followed by treatment with O-methylhydroxylamine hydrochloride. This combination of reagents could provide a complementary method to catalytic hydrogenolysis, which certainly cleaves N-arylmethyl groups, in organic synthesis. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：598 / 600

页数：3

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