Successful management of massive lamotrigine extended-release intoxication in a dog

被引:0
作者
McLaine, Alexis S. [1 ]
Yaxley, Page E. [1 ]
Young, Anda A. [1 ]
Cooper, Edward S. [1 ]
机构
[1] Ohio State Univ, Dept Vet Clin Sci, Columbus, OH 43210 USA
来源
CLINICAL CASE REPORTS | 2021年 / 9卷 / 12期
关键词
cardiovascular disorders; lamotrigine; neurologic disorders; toxicology; veterinary; INTRAVENOUS LIPID EMULSION; PHARMACOLOGICAL-PROPERTIES; PHARMACOKINETICS; TOXICITY; OVERDOSE; CHARCOAL; THERAPY;
D O I
10.1002/ccr3.5169
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 3-year-old spayed female Siberian Husky presented for evaluation following ingestion of approximately 429 mg/kg of lamotrigine extended-release. She demonstrated severe neurologic and cardiac signs and was treated with lipid emulsion, anticonvulsants, antiarrhythmics and aggressive decontamination and supportive care. She was successfully discharged from the hospital 5 days later.
引用
收藏
页数:10
相关论文
共 50 条
  • [31] Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology
    Polepally, Akshanth R.
    Remmel, Rory P.
    Brundage, Richard C.
    Leppik, Ilo E.
    Rarick, John O.
    Ramsay, R. Eugene
    Birnbaum, Angela K.
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 55 (10) : 1101 - 1108
  • [32] Liposomal extended-release bupivacaine for postsurgical analgesia
    Lambrechts, Mark
    O'Brien, Michael J.
    Savoie, Felix H.
    You, Zongbing
    [J]. PATIENT PREFERENCE AND ADHERENCE, 2013, 7 : 885 - 890
  • [33] Extended-release oral treprostinil in the management of pulmonary arterial hypertension: clinical evidence and experience
    Coons, James C.
    Miller, Taylor
    [J]. THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2018, 12
  • [34] Venlafaxine extended-release - A review of its clinical potential in the management of generalised anxiety disorder
    Balfour, JAB
    Jarvis, B
    [J]. CNS DRUGS, 2000, 14 (06) : 483 - 503
  • [35] Extended-release oral capsule of carbidopa-levodopa in Parkinson disease
    Margolesky, Jason
    Singer, Carlos
    [J]. THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2017, 11 : 1 - 12
  • [36] Administration of crushed extended-release pentoxifylline tablets: Bioavailability and adverse effects
    Cleary, JD
    Evans, PC
    Hikal, AH
    Chapman, SW
    [J]. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 1999, 56 (15) : 1529 - 1534
  • [37] Steady-state pharmacokinetics of lamotrigine when converting from a twice-daily immediate-release to a once-daily extended-release formulation in subjects with epilepsy (The COMPASS Study)
    Tompson, Debra J.
    Ali, Imran
    Oliver-Willwong, Ruth
    Job, Sarah
    Zhu, Li
    Lemme, Francesca
    Hammer, Anne E.
    Vuong, Alain
    Messenheimer, John A.
    [J]. EPILEPSIA, 2008, 49 (03) : 410 - 417
  • [38] Successful Management of Severe Bromethalin Toxicosis in a Dog
    Lyons, Bridget M.
    Poppenga, Robert H.
    Thawley, Vincent J.
    Waddell, Lori S.
    [J]. JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 2019, 55 (05)
  • [39] Maintaining remission in ulcerative colitis - role of once daily extended-release mesalamine
    Oliveira, Lilliana
    Cohen, Russell D.
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2011, 5 : 111 - 116
  • [40] Retrospective assessment of the use of extended-release cabergoline in the management of equine pituitary pars intermedia dysfunction
    Sundra, Tania
    Kelty, Erin
    Rossi, Gabriele
    Rendle, David
    [J]. FRONTIERS IN VETERINARY SCIENCE, 2024, 11