APC resistance due to factor v Leiden mutation presenting as acute hemorrhagic jejunal infarction - Case report

被引:0
作者
Garlipp, B. [1 ]
Gerhardt, U. [2 ]
Linke, J. [3 ]
Arlt, G. [1 ]
机构
[1] Pk Klin Weissensee, Abt Allgemeine Viszeral & Unfallchirurg, D-13086 Berlin, Germany
[2] Pk Klin Weissensee, Abt Bildgebende Diagnost, Berlin, Germany
[3] Gemeinschpraxis Pathol, Berlin, Germany
来源
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2008年 / 46卷 / 02期
关键词
mesenteric vein occlusion; hemorrhagic jejunal infarction; factor V Leiden mutation; APC-resistance;
D O I
10.1055/s-2007-963528
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
We report on a 43-year-old patient presenting to the emergency department with acute abdominal pain the source of which turned out to be acute hemorrhagic jejunal infarction due to portal and mesenteric vein occlusion with no apparent cause. In spite of a lacking history of hereditary thrornbophilic risk factors, further diagnostic procedures revealed heterozygous factor V Leiden mutation. Diagnosis, therapy and clinical course are described. An overview on acute mesenteric venous occlusion with special reference to genetically determined thrombophilic disorders is given.
引用
收藏
页码:206 / 210
页数:5
相关论文
共 50 条
[31]   Factor V Leiden and the Risk of Venous Thrombosis, Myocardial Infarction, and Stroke: A Case-Control Study in Venezuela [J].
Pestana, Carolina I. ;
Torres, Argimiro ;
Blanco, Susana ;
Rojas, Maria J. ;
Mendez, Carlos ;
Lopez, Jose L. ;
de Bosch, Norma B. ;
Porco, Antonietta .
GENETIC TESTING AND MOLECULAR BIOMARKERS, 2009, 13 (04) :537-542
[32]   Factor V Leiden mutation, in-utero inferior vena cava and renal vein thrombosis: report of successful retroperitoneoscopic nephrectomy. Case report No. 1 [J].
El-Saify, Wael M. ;
El-Saify, Mariam M. R. ;
Tsang, T. ;
Mathur, A. B. ;
Kulkarni, M. .
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, 2007, 39 (05) :317-320
[33]   Pseudo-homozygous activated protein C resistance due to coinheritance of heterozygous factor V Leiden mutation and type I factor V deficiency. Variable expression when analyzed by different activated protein C resistance functional assays [J].
Delahousse, B ;
Iochmann, S ;
Pouplard, C ;
Fimbel, B ;
Charbonnier, B ;
Gruel, Y .
BLOOD COAGULATION & FIBRINOLYSIS, 1997, 8 (08) :503-509
[34]   Prevalence of factor V Leiden mutation in young adults with cerebral ischaemia: a case-control study on 225 patients [J].
D. G. Nabavi ;
Ralf Junker ;
Endrik Wolff ;
Peter Lüdemann ;
Christopher Doherty ;
Stefan Evers ;
Dirk W. Droste ;
Christof Kessler ;
Gerd Assmann ;
E. Bernd Ringelstein .
Journal of Neurology, 1998, 245 :653-658
[35]   Prevalence of factor V Leiden mutation in young adults with cerebral ischaemia: a case-control study on 225 patients [J].
Nabavi, DG ;
Junker, R ;
Wolff, E ;
Ludemann, P ;
Doherty, C ;
Evers, S ;
Droste, DW ;
Kessler, C ;
Assmann, G ;
Ringelstein, FB .
JOURNAL OF NEUROLOGY, 1998, 245 (10) :653-658
[36]   The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors [J].
Rehak, Matus ;
Rehak, Jiri ;
Mueller, Marc ;
Faude, Susanne ;
Faude, Frank ;
Siegemund, Annelie ;
Krcova, Vera ;
Slavik, Ludek ;
Hasenclever, Dirk ;
Scholz, Markus ;
Wiedemann, Peter .
THROMBOSIS AND HAEMOSTASIS, 2008, 99 (05) :925-929
[37]   Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management [J].
Pose, Randi M. ;
Knipper, Sophie ;
Ekrutt, Jonas ;
Koelker, Mara ;
Tennstedt, Pierre ;
Heinzer, Hans ;
Tilki, Derya ;
Langer, Florian ;
Graefen, Markus .
ASIAN JOURNAL OF UROLOGY, 2024, 11 (01) :42-47
[38]   Factor V:Q506 mutation -: Resistance to activated protein C (APC):: Clinical implications with respect to family screening [J].
Middeldorp, S ;
van der Meer, J .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1998, 24 (04) :363-366
[39]   Resistance to activated protein C (APC): Mutation at ARG(506) of coagulation factor V and vascular access thrombosis in haemodialysis patients [J].
Fodinger, M ;
Mannhalter, C ;
Pabinger, I ;
Koizar, D ;
Rintelen, C ;
Horl, WH ;
SunderPlassmann, G .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1996, 11 (04) :668-672
[40]   Acute renal artery and vein thrombosis after renal transplant, associated with a short partial thromboplastin time and factor V Leiden mutation [J].
Guirguis, N ;
Budisavljevic, MN ;
Self, S ;
Rajagopalan, PR ;
Lazarchick, J .
ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2000, 30 (01) :75-78