Catalytic enantioselective protonation of a samarium enolate with fluorous chiral and achiral proton sources in fluorous biphasic systems

被引：63

作者：

Takeuchi, S

Nakamura, Y

Ohgo, Y

Curran, DP

机构：

[1] Niigata Coll Pharm, Niigata 9502081, Japan

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

基金：

美国国家卫生研究院;

关键词：

fluorine and compounds; asymmetric; catalysis; protonation;

D O I：

10.1016/S0040-4039(98)01900-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselectivities near maximum values were obtained in the catalytic reaction by a rapid addition of a fluorous achiral alcohol (Rfh(3)C-OH) to the reaction mixture:for DHPEX in Rfh(3)C-OH/THF solid-liquid biphase system and for a fluorous chiral alcohol in THF/FC-72 liquid-liquid biphase system. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8691 / 8694

页数：4