Uncovering the transmission dynamics of Plasmodium vivax using population genetics

被引：49

作者：

Barry, Alyssa E. ^{[1
,2
]}

Waltmann, Andreea ^{[1
,2
]}

Koepfli, Cristian ^{[1
,2
]}

Barnadas, Celine ^{[1
,2
,3
]}

Mueller, Ivo ^{[1
,2
,4
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Melbourne, Vic, Australia

[3] PNG Inst Med Res, Goroka, Papua N Guinea

[4] Barcelona Ctr Int Hlth Res, Barcelona, Spain

来源：

PATHOGENS AND GLOBAL HEALTH | 2015年 / 109卷 / 03期

基金：

英国医学研究理事会;

关键词：

Malaria; Plasmodium vivax; Transmission; Relapse; Genetics; Genomics; Genetic diversity; Population structure; Linkage disequilibrium; Microsatellites; Single nucleotide polymorphisms; Mitochondrial DNA; Control; Elimination; MITOCHONDRIAL GENOME SEQUENCES; REPUBLIC-OF-KOREA; MICROSATELLITE DIVERSITY; PARASITE POPULATIONS; EVOLUTIONARY HISTORY; ASYMPTOMATIC MALARIA; MOLECULAR ANALYSIS; DRUG-RESISTANCE; FALCIPARUM; INFECTIONS;

D O I：

10.1179/2047773215Y.0000000012

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Population genetic analysis of malaria parasites has the power to reveal key insights into malaria epidemiology and transmission dynamics with the potential to deliver tools to support control and elimination efforts. Analyses of parasite genetic diversity have suggested that Plasmodium vivax populations are more genetically diverse and less structured than those of Plasmodium falciparum indicating that P. vivax may be a more ancient parasite of humans and/or less susceptible to population bottlenecks, as well as more efficient at disseminating its genes. These population genetic insights into P. vivax transmission dynamics provide an explanation for its relative resilience to control efforts. Here, we describe current knowledge on P. vivax population genetic structure, its relevance to understanding transmission patterns and relapse and how this information can inform malaria control and elimination programmes.

引用

页码：142 / 152

页数：11

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