MetazExp: a database for gene expression and alternative splicing profiles and their analyses based on 53 615 public RNA-seq samples in 72 metazoan species

被引:4
作者
Liu, Jinding [1 ,2 ,3 ]
Yin, Fei [2 ]
Lang, Kun [1 ,2 ]
Jie, Wencai [4 ]
Tan, Suxu [3 ]
Duan, Rongjing [5 ]
Huang, Shuiqing [1 ,2 ]
Huang, Wen [3 ]
机构
[1] Nanjing Agr Univ, Coll Informat Management, Nanjing 210095, Jiangsu, Peoples R China
[2] Nanjing Agr Univ, Res Ctr Correlat Domain Knowledge, Nanjing 210095, Jiangsu, Peoples R China
[3] Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA
[4] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
[5] Nanjing Agr Univ, Acad Adv Interdisciplinary Studies, Nanjing 210095, Jiangsu, Peoples R China
关键词
REVEALS; PACKAGE;
D O I
10.1093/nar/gkab933
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RNA-seq has been widely used in experimental studies and produced a massive amount of data deposited in public databases. New biological insights can be obtained by retrospective analyses of previously published data. However, the barrier to efficiently utilize these data remains high, especially for those who lack bioinformatics skills and computational resources. We present MetazExp (https://bioinfo.njau.edu.cn/metazExp), a database for gene expression and alternative splicing profiles based on 53 615 uniformly processed publicly available RNA-seq samples from 72 metazoan species. The gene expression and alternative splicing profiles can be conveniently queried by gene IDs, symbols, functional terms and sequence similarity. Users can flexibly customize experimental groups to perform differential and specific expression and alternative splicing analyses. A suite of data visualization tools and comprehensive links with external databases allow users to efficiently explore the results and gain insights. In conclusion, MetazExp is a valuable resource for the research community to efficiently utilize the vast public RNA-seq datasets.
引用
收藏
页码:D1046 / D1054
页数:9
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