Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients

被引:11
作者
Hayashi, Tsuguru [1 ,2 ]
Tamaki, Nobuharu [1 ]
Kurosaki, Masayuki [1 ]
Wang, Wan [1 ]
Okada, Mao [1 ]
Higuchi, Mayu [1 ]
Takaura, Kenta [1 ]
Takada, Hitomi [1 ]
Yasui, Yutaka [1 ]
Tsuchiya, Kaoru [1 ]
Nakanishi, Hiroyuki [1 ]
Itakura, Jun [1 ]
Harada, Masaru [2 ]
Izumi, Namiki [1 ]
机构
[1] Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan
[2] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka 8078555, Japan
关键词
WFA(+)-M2BP; chronic hepatitis C; gastroesophageal varices; SIMPLE NONINVASIVE INDEX; RADIATION FORCE IMPULSE; ESOPHAGEAL-VARICES; STIFFNESS MEASUREMENT; HEPATOCELLULAR-CARCINOMA; TRANSIENT ELASTOGRAPHY; MAC-2-BINDING PROTEIN; SIGNIFICANT FIBROSIS; PORTAL-HYPERTENSION; CIRRHOSIS;
D O I
10.3390/diagnostics10030173
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. Results: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA(+)-M2BP) levels increased according to the grade of GEV (3.4 (0.2-18.6) for no GEV, 7.9 (1.8-20.0) for small GEV, and 11.4 (4.0-20.0) for large GEV; p < 0.001). The diagnostic accuracy of the WFA(+)-M2BP was superior compared to other serum fibrosis markers, and WFA(+)-M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA(+)-M2BP levels <= 7.0 and 37.5% in patients with WFA(+)-M2BP levels > 7.0 (p < 0.001). WFA(+)-M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7, p = 0.004) independent of Child-Pughclass. Conclusions: WFA(+)-M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.
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页数:10
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