共 37 条
Use of the Serum Wisteria floribunda Agglutinin-Positive Mac2 Binding Protein as a Marker of Gastroesophageal Varices and Liver-Related Events in Chronic Hepatitis C Patients
被引:11
作者:

Hayashi, Tsuguru
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h-index: 0
机构:
Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan
Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka 8078555, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Tamaki, Nobuharu
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Kurosaki, Masayuki
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Wang, Wan
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h-index: 0
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Okada, Mao
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Higuchi, Mayu
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Takaura, Kenta
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Takada, Hitomi
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Yasui, Yutaka
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Tsuchiya, Kaoru
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Nakanishi, Hiroyuki
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Itakura, Jun
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Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Harada, Masaru
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h-index: 0
机构:
Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka 8078555, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan

Izumi, Namiki
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h-index: 0
机构:
Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan
机构:
[1] Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo 1808610, Japan
[2] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka 8078555, Japan
来源:
关键词:
WFA(+)-M2BP;
chronic hepatitis C;
gastroesophageal varices;
SIMPLE NONINVASIVE INDEX;
RADIATION FORCE IMPULSE;
ESOPHAGEAL-VARICES;
STIFFNESS MEASUREMENT;
HEPATOCELLULAR-CARCINOMA;
TRANSIENT ELASTOGRAPHY;
MAC-2-BINDING PROTEIN;
SIGNIFICANT FIBROSIS;
PORTAL-HYPERTENSION;
CIRRHOSIS;
D O I:
10.3390/diagnostics10030173
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background: A test to narrow down patients who require esophagogastroduodenoscopy (EGD) with a high probability of having gastroesophageal varices (GEV) and a high-risk of liver-related events is an unmet need. Methods: The measurement of serum fibrosis markers and EGD was performed in 166 consecutive chronic hepatitis C patients. The correlation between the grades of GEV and fibrosis markers and the subsequent occurrence of liver-related and fibrosis markers were examined. Results: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA(+)-M2BP) levels increased according to the grade of GEV (3.4 (0.2-18.6) for no GEV, 7.9 (1.8-20.0) for small GEV, and 11.4 (4.0-20.0) for large GEV; p < 0.001). The diagnostic accuracy of the WFA(+)-M2BP was superior compared to other serum fibrosis markers, and WFA(+)-M2BP was an independent predictor of GEV in the multivariate analysis. Furthermore, the cumulative incidence of liver-related events at one year was 2.3% in patients with WFA(+)-M2BP levels <= 7.0 and 37.5% in patients with WFA(+)-M2BP levels > 7.0 (p < 0.001). WFA(+)-M2BP > 7.0 was a significant predictive factor for liver-related events (Hazard ratio 6.7, p = 0.004) independent of Child-Pughclass. Conclusions: WFA(+)-M2BP could be used to estimate the presence and grade of GEV and is linked to liver-related events in chronic hepatitis C patients.
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页数:10
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机构: Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy

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Fasoli, A
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机构: Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy

Malfatti, F
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机构: Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy

Romagnoli, P
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Testa, E
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机构: Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy

Ceppa, P
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Testa, R
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[10]
Impact of serum glycosylated Wisteria floribunda agglutinin positive Mac-2 binding protein levels on liver functional reserves and mortality in patients with liver cirrhosis
[J].
Hanai, Tatsunori
;
Shiraki, Makoto
;
Ohnishi, Sachiyo
;
Miyazaki, Tsuneyuki
;
Ideta, Takayasu
;
Kochi, Takahiro
;
Imai, Kenji
;
Suetsugu, Atsushi
;
Takai, Koji
;
Shimizu, Masahito
;
Moriwaki, Hisataka
.
HEPATOLOGY RESEARCH,
2015, 45 (11)
:1083-1090

Hanai, Tatsunori
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Shiraki, Makoto
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Ohnishi, Sachiyo
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Miyazaki, Tsuneyuki
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Ideta, Takayasu
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Kochi, Takahiro
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Imai, Kenji
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Suetsugu, Atsushi
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Takai, Koji
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Shimizu, Masahito
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan

Moriwaki, Hisataka
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Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan Gifu Univ, Dept Gastroenterol Internal Med, Grad Sch Med, Gifu 5011194, Japan