Anti-estrogenic compounds from Liliceae plants, Polygonatum falcatum and Allium schoenoprasum

被引：0

作者：

Umehara, Kaoru ^{[1
]}

Nemoto, Kiyomitsu ^{[1
]}

Sutoh, Miwako ^{[1
]}

Miyase, Toshio ^{[1
]}

Degawa, Masakuni ^{[1
]}

Noguchi, Hiroshi ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Shizuoka 4228526, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2007年 / 127卷

关键词：

Polygonatum falcatum; Allium schoenoprasum; Liliaceae; anti-estrogenic activity; spirostenol glycoside;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While searching for new anti-estrogenic compounds from plant kingdom, we investigated extracts of the rhizomes of Polygonatum falcatum and the aerial part of Allium schoenoprasum (Liliaceae). Four new spirostenol glycosides along with 9 known compounds have been isolated and characterized. Isolates were evaluated for their anti-estrogenic activity using estrogen responsive/unresponsive human breast cancer cell lines. Disogenin lycotetraosides (1, 2) were the most effective compounds and suppressed the estradiol (E2)-induced cell proliferation of MCF-7 and T47D at a concentration of 100 pM. Prazerigenin lycotetraosides (3 - 6) also showed the activity but needed 100 times higher concentration of the diosgenin lycotetraosides. Another diosgenin glycoside (9) which has rhamnose in its sugar chain suppressed not only E2-induced cell proliferation but also E2 unresponsive cell proliferation. To determine the estrogenic characteristics of the active constituents, the luciferase(luc) reporter assay using ERE-luc transfected MCF-7 (MCF-7/luc) and ERE-luc transfected T47D (T47D/luc) cells was carried out.

引用

页码：102 / 104

页数：3