The Hunger Genes: Pathways to Obesity

被引：273
|
作者：
van der Klaauw, Agatha A. [1 ,2 ]
Farooqi, I. Sadaf [1 ,2 ]
机构：
[1] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England
[2] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, NIHR Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England
来源：
CELL | 2015年 / 161卷 / 01期
基金：
英国惠康基金;
关键词：
BODY-MASS INDEX; MELANOCYTE-STIMULATING HORMONE; MELANOCORTIN-4 RECEPTOR MUTATIONS; EARLY-ONSET OBESITY; FTO GENE; HUMAN LEPTIN; FOOD-INTAKE; HYPOTHALAMIC NEURONS; RECOMBINANT LEPTIN; ENERGY-EXPENDITURE;
D O I：
10.1016/j.cell.2015.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions.
引用
收藏
页码：119 / 132
页数：14
相关论文
共 50 条
  • [21] Role of the Polymorphisms of Uncoupling Protein Genes in Childhood Obesity and Their Association with Obesity-Related Disturbances
    Gul, Ali
    Ates, Omer
    Ozer, Samet
    Kasap, Tuba
    Ensari, Emel
    Demir, Osman
    Sonmezgoz, Ergun
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2017, 21 (09) : 531 - 538
  • [22] Contextual factors associated with eating in the absence of hunger among adults with obesity
    Goldschmidt, Andrea B.
    Crosby, Ross D.
    Cao, Li
    Pearson, Carolyn M.
    Utzinger, Linsey M.
    Pacanowski, Carly R.
    Mason, Tyler B.
    Berner, Laura A.
    Engel, Scott G.
    Wonderlich, Stephen A.
    Peterson, Carol B.
    EATING BEHAVIORS, 2017, 26 : 33 - 39
  • [23] Hunger and Satiety Signaling: Modeling Two Hypothalamomedullary Pathways for Energy Homeostasis
    Nakamura, Kazuhiro
    Nakamura, Yoshiko
    BIOESSAYS, 2018, 40 (08)
  • [24] Multilocus Analyses of Seven Candidate Genes Suggest Interacting Pathways for Obesity-Related Traits in Brazilian Populations
    Angeli, Claudia B.
    Kimura, Lilian
    Auricchio, Maria T.
    Vicente, Joao P.
    Mattevi, Vanessa S.
    Zembrzuski, Veronica M.
    Hutz, Mara H.
    Pereira, Alexandre C.
    Pereira, Tiago V.
    Mingroni-Netto, Regina C.
    OBESITY, 2011, 19 (06) : 1244 - 1251
  • [25] Obesity, More than a 'Cosmetic' Problem. Current Knowledge and Future Prospects of Human Obesity Genetics
    Shabana
    Hasnain, Shahida
    BIOCHEMICAL GENETICS, 2016, 54 (01) : 1 - 28
  • [26] FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences
    Popovic, Ana-Marija
    Turkovic, Ana Hudek
    Zuna, Kristina
    Bacun-Druzina, Visnja
    Rubelj, Ivica
    Matovinovic, Martina
    FOOD TECHNOLOGY AND BIOTECHNOLOGY, 2023, 61 (01) : 14 - 26
  • [27] Obesity: from genes to behaviour
    Farooqi, I. Sadaf
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2014, 171 (05) : R191 - R195
  • [28] Genetic approaches to understanding human obesity
    Ramachandrappa, Shwetha
    Farooqi, I. Sadaf
    JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) : 2080 - 2086
  • [29] Developmental pathways leading to obesity in childhood
    Hejazi, Samar
    Dahinten, V. Susan
    Marshall, Sheila K.
    Ratner, Pamela A.
    HEALTH REPORTS, 2009, 20 (03)
  • [30] Plant compounds for obesity treatment through neuroendocrine regulation of hunger: A systematic review
    Boix-Castejon, M.
    Roche, E.
    Olivares-Vicente, M.
    Alvarez-Martinez, F. J.
    Herranz-Lopez, M.
    Micol, V.
    PHYTOMEDICINE, 2023, 113
12345