The Hunger Genes: Pathways to Obesity

被引：273
|
作者：
van der Klaauw, Agatha A. [1 ,2 ]
Farooqi, I. Sadaf [1 ,2 ]
机构：
[1] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England
[2] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, NIHR Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England
来源：
CELL | 2015年 / 161卷 / 01期
基金：
英国惠康基金;
关键词：
BODY-MASS INDEX; MELANOCYTE-STIMULATING HORMONE; MELANOCORTIN-4 RECEPTOR MUTATIONS; EARLY-ONSET OBESITY; FTO GENE; HUMAN LEPTIN; FOOD-INTAKE; HYPOTHALAMIC NEURONS; RECOMBINANT LEPTIN; ENERGY-EXPENDITURE;
D O I：
10.1016/j.cell.2015.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, and behavioral pathways involved in the development of obesity in susceptible individuals is critical for identifying effective mechanism-based preventative and therapeutic interventions.
引用
收藏
页码：119 / 132
页数：14
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