Concise synthesis of 2-amino-4(3H)-quinazolinones from simple (Hetero)aromatic amines

被引：36

作者：

Zeghida, Walid ^{[1
]}

Debray, Julien ^{[1
]}

Chierici, Sabine ^{[1
]}

Durny, Pascal ^{[1
]}

Demeunynck, Martine ^{[1
]}

机构：

[1] Univ Grenoble 1, Dept Chim Mol, UMR 5250, F-38041 Grenoble, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 06期

关键词：

D O I：

10.1021/jo7026883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and simple method of preparation of 2-alkylaminoquinazolin-4-ones with fused heteroaromatic rings from easily accessible (hetero) aromatic amines is described. The method is very efficient, and the 2-alkylaminoquinazolinone derivatives are obtained in three steps without chromatographic purification. The key step is the ring closure of the N-protected guanidine intermediates by intramolecular Friedel-Craft's type substitution.

引用

页码：2473 / 2475

页数：3

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