Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria

被引：28

作者：

Cione, E. ^{[1
]}

Tucci, P. ^{[1
]}

Senatore, V. ^{[1
]}

Perri, M. ^{[1
]}

Trombino, S. ^{[2
]}

Iemma, F. ^{[2
]}

Picci, N. ^{[2
]}

Genchi, G. ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Farmaco Biol, Biochim Lab, I-87036 Arcavacata Di Rende, CS, Italy

[2] Univ Calabria, Dipartimento Sci Farmaceut, Chim Organ Lab, I-87036 Arcavacata Di Rende, CS, Italy

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2008年 / 40卷 / 01期

关键词：

ferulic acid; cytochrome c; apoptosis; mitochondria; TM-3; cells; MLTC-1;

D O I：

10.1007/s10863-007-9097-7

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis. As mitochondria play a key role in the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1 cells. While ferulic acid, but not its esters, induced MPT and cytochrome c release in rat testes isolated mitochondria, in TM-3 cells we found that both ferulic acid and its esters induced cytochrome c release from mitochondria in a dose-dependent manner, suggesting a potential target of these compounds in the induction of cell apoptosis. The apoptosis induced by ferulic acid is therefore associated with the mitochondrial pathway involving cytochrome c release and caspase-3 activation.

引用

页码：19 / 26

页数：8

共 30 条

[1] Influence of the redox state of pyridine nucleotides on mitochondrial sulfhydryl groups and permeability transition [J].