Synthesis and transformations of 2-amino-1-(4,5-dihydro-1H-imidazol-2-yl)benzimidazoles. A route to 2,3-dihydrobenzo[4,5]imidazo[1,2-c]imidazo[1,2-a][1,3,5]triazine ring system

被引：3

作者：

Saczewski, F ^{[1
]}

Debowski, T ^{[1
]}

Szmigiel, J ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Organ Chem, Gdansk, Poland

来源：

HETEROCYCLES | 1998年 / 48卷 / 09期

关键词：

D O I：

10.3987/COM-98-8222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 3-(4,5-dihydro-1H-imidazol-2-yl)-2-oxo-2,3-dihydrobenzimidazole-1-carbonitriles (la-e) the 2-amino-1-(4,5-dihydro-1H-imidazol-2-yl)benzimidazoles (2a-e) and 1-(4,5-dihydro-1H-imidazol-2-yl)-2-oxo-2,3-dihydrobenzimidazoles (3a-e) have been synthesized. Cyclocondensation of 2a with acetic anhydride or acyl chlorides gave novel functionalized 2,3-dihydrobenzo[4,5]imidazo[1,2-c]imidazo[1,2-a]triazines (4a-d).

引用

页码：1879 / 1885

页数：7

共 19 条

[1] SYNTHESIS AND ANTITRICHOMONAL ACTIVITY OF AZINIUM (AZOLIUM) 4-NITROBENZIMIDAZOLATE BETAINES AND THEIR DERIVATIVES [J].

ALCALDE, E ;

PEREZGARCIA, L ;

DINARES, I ;

COOMBS, GH ;

FRIGOLA, J .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (02) :171-176

[2]

BADAWEY EAM, 1993, ARCFH PHARM, V325, P565

[3]

BANKS BJ, 1994, Patent No. 9318010

[4]

CAROTI P, 1989, FARMACO, V44, P227

[5]

DASETTIMO A, 1992, FARMACO, V47, P1293

[6] CLASS-III ANTIARRHYTHMIC ACTIVITY OF NOVEL SUBSTITUTED 4-[(METHYLSULFONYL)AMINO]BENZAMIDES AND SULFONAMIDES [J].

ELLINGBOE, JW ;

SPINELLI, W ;

WINKLEY, MW ;

NGUYEN, TT ;

PARSONS, RW ;

MOUBARAK, IF ;

KITZEN, JM ;

VONENGEN, D ;

BAGLI, JF .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (04) :705-716

[7]

Grimmett M.R., 1984, COMPREHENSIVE HETERO, V5, P345

[8]

KITRITZKI AR, 1990, SYNTHESIS-STUTTGART, P561

[9] Information on substituted alpha-hydroxyl- and alpha-methyl-benzimide-azole [J].

Kym, O ;

Ratner, L .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1912, 45 :3238-3255

[10]

MENZER M, 1991, Patent No. 281383

← 1 2 →