Asymmetric P-C Bond Formation: Diastereoselective Synthesis of Adjacent P,C-Stereogenic Allylic Phosphorus Compounds

被引：13

作者：

Xie, Peizhong ^{[1
]}

Guo, Lei ^{[1
]}

Xu, Lanlan ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Coll Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2016年 / 11卷 / 09期

关键词：

1,3-bisphosphinylpropanes; kinetic resolution; organocatalysis; P-C bond formation; P-stereogenic compounds; BAYLIS-HILLMAN CARBONATES; ALPHA; BETA-UNSATURATED ALDEHYDES; PHOSPHINE OXIDES; HYDROGENATION; SUBSTITUTION; KETONES; ESTERS; HYDROPHOSPHINATION; CONSTRUCTION; NUCLEOPHILES;

D O I：

10.1002/asia.201600108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel catalytic asymmetric P-C bond formation between phosphinates/ phosphine oxide and allylic carbonates was developed. This methodology could not only afford a variety of functionalized adjacent P,C-stereogenic phosphorus compounds in high yields with high regio- and diastereoselectivities but also provide an alternative strategy to access enantiomerically enriched (S-P)-phosphinates through kinetic resolution.

引用

页码：1353 / 1356

页数：4

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