pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

被引：31

作者：

Shin, Younghyun ^{[1
]}

Kim, Dajung ^{[1
]}

Hu, Yiluo ^{[1
]}

Kim, Yohan ^{[1
]}

Hong, In Ki ^{[2
]}

Kim, Moo Sung ^{[3
]}

Jung, Seunho ^{[1
,4
,5
]}

机构：

[1] Konkuk Univ, Ctr Biotechnol Res UBITA CBRU, Dept Biosci & Biotechnol, Seoul 05029, South Korea

[2] Kolmar Korea, Covergence Technol Lab, 61,Heolleung Ro 8 Gil, Seoul 06800, South Korea

[3] Macrocare, 32 Gangni 1 Gil, Cheongju 28126, South Korea

[4] Konkuk Univ, Ctr Biotechnol Res UBITA CBRU, Dept Syst Biotechnol, Seoul 05029, South Korea

[5] Konkuk Univ, Inst Ubiquitous Informat Technol & Applicat UBITA, Seoul 05029, South Korea

来源：

POLYMERS | 2021年 / 13卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

hydrogels; carboxymethyl cellulose; succinoglycan; metal coordination; drug delivery; swelling properties; GELATIN HYDROGELS; XANTHAN GUM; ACID; POLYACRYLAMIDE; POLYMERIZATION; COORDINATION; RELEASE; BEADS; FE3+;

D O I：

10.3390/polym13183197

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G ') at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

引用

页数：16

共 59 条

[1] Gelation Rheology and Water Absorption Behavior of Semi-Interpenetrating Polymer Networks of Polyacrylamide and Carboxymethyl Cellulose [J].