Association between baseline LH/FSH and live-birth rate after fresh-embryo transfer in polycystic ovary syndrome women

被引：24

作者：

Su, Nian-jun ^{[1
]}

Huang, Cui-yu ^{[1
]}

Liu, Jie ^{[2
]}

Kang, De-ying ^{[3
]}

Wang, Song-lu ^{[1
]}

Liao, Liu-jun ^{[1
]}

Yang, Jin-di ^{[1
]}

Zhang, Xi-qian ^{[1
]}

Liu, Feng-hua ^{[1
]}

机构：

[1] Guangdong Women & Children Hosp, Dept Reprod Hlth & Infertil, 521 Xingnan Ave, Guangzhou 511442, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Vasc & Endovasc Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Evidence Based Med & Clin Epidemiol, 37 Guoxuexiang, Chengdu 610041, Peoples R China

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

ANTI-MULLERIAN HORMONE; INFERTILITY; PREVALENCE; ULTRASOUND; CYCLES; SINGLE;

D O I：

10.1038/s41598-021-99850-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.

引用

页数：9

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