A dual-site two-photon fluorescent probe for visualizing mitochondrial aminothiols in living cells and mouse liver tissues

被引：20

作者：

Meng, Fangfang ^{[1
]}

Liu, Yong ^{[1
]}

Yu, Xiaoqiang ^{[2
]}

Lin, Weiying ^{[1
]}

机构：

[1] Univ Jinan, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China

[2] Shandong Univ, State Key Lab Crystal Mat, Ctr Bio & Micro Nano Funct Mat, Jinan 250100, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 09期

关键词：

AIE LUMINOGEN; HOMOCYSTEINE; GLUTATHIONE; DERIVATIVES; TRACKING; CYSTEINE; ACID;

D O I：

10.1039/c6nj00330c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thiol-containing amino acids ( RSH) play a key role in maintaining the redox environment. In this work, we developed a novel dual-site two-photon ( TP) fluorescent RSH probe ( CA-TPP) for imaging mitochondrial RSH in living cells and mouse liver tissues. This probe exhibited rapid response and high TP photostability towards mitochondrial RSH. In particular, probe CA-TPP was capable of using TP fluorescence to track mitochondrial RSH over a long period.

引用

页码：7399 / 7406

页数：8

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