Tricin from a Malagasy connaraceous plant with potent antihistaminic activity

被引：48
|
作者：
Kuwabara, H [1 ]
Mouri, K [1 ]
Otsuka, H [1 ]
Kasai, R [1 ]
Yamasaki, K [1 ]
机构：
[1] Hiroshima Univ, Dept Pharmacognosy, Div Med Chem, Grad Sch Biomed Sci,Minami Ku, Hiroshima 7348551, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 09期
关键词：
D O I：
10.1021/np030020p
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The bioassay-guided separation of a Malagasy plant, Agelaea pentagyna, led to the isolation of a flavonoid, tricin (1), with potent inhibitory activity toward exocytosis from antigen-stimulated rat leukemia basophils (RBL-2H3). The structure-activity relationships among structurally related natural and synthetic flavonoids are also discussed.
引用
收藏
页码：1273 / 1275
页数：3
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