Na plus channel mutations and epilepsy

被引：1

作者：

Catterall, William A. ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

来源：

EPILEPSIA | 2010年 / 51卷

关键词：

Benign familial neonatal-infantile seizures; Dravet's syndrome; Generalized epilepsy with febrile seizures plus; Inhibitory interneurons; Severe myoclonic epilepsy of infancy; Seizures;

D O I：

10.1111/j.1528-1167.2010.02845.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Voltage-gated Na+ channels are the molecular targets for mutations that cause several epilepsy syndromes. Mutations that impair the function of NaV1.1 channels cause reduced Na+ currents and failure of electrical excitability in γγ-aminobutyric acid (GABA)ergic interneurons, providing a potential mechanism for hyperexcitability in a spectrum of Na+ channel epilepsy syndromes. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.

引用

页码：59 / 59

页数：1

共 4 条

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