Interindividual differences in phytochemical metabolism and disposition

被引：84

作者：

Lampe, Johanna W.

Chang, Jyh-Lurn

机构：

[1] Univ Washington, Dept Epidemiol, Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Univ Washington, Dept Epidemiol, Nutr Sci Program, Seattle, WA 98109 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 05期

关键词：

phytochemical; gut bacteria; genetic polymorphism; phase II biotransformation enzyme; interindividual variation;

D O I：

10.1016/j.semcancer.2007.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many phytochemicals, the bioactive nonnutrient compounds found in plant foods, possess biologic effects associated with reduced risk of various diseases such as cancer. Genetic variation in pathways affecting absorption, metabolism, and distribution of phytochemicals is likely to influence exposure at the tissue level, thus modifying disease risk in individuals. Few studies have examined these gene-phytochemical interactions in humans. In this review, we discuss the sources of variation in metabolism and disposition of phytochemicals, and focus on two aspects of phytochemical handling that have received some attention: the impact of intestinal bacteria and genetically polymorphic phase II, conjugating enzymes. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：347 / 353

页数：7

共 67 条

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