Chromatin remodeling complexes: strength in diversity, precision through specialization

被引：133
作者：
Cairns, BR
机构：
[1] Univ Utah, Sch Med, Dept Oncol Sci, Salt Lake City, UT 84112 USA
[2] Univ Utah, Sch Med, Howard Hughes Med Inst, Huntsman Canc Inst, Salt Lake City, UT 84112 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 02期
关键词：
D O I：
10.1016/j.gde.2005.01.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chromatin remodeling complexes all have an ATPase subunit important for nucleosome remodeling, but are diversified and specialized by additional associated proteins. Remodelers have well-established roles in a wide range of chromosomal processes, including transcriptional regulation and chromatin assembly. Recent work, however, has revealed remarkable new functions for remodelers, such as histone variant deposition, cohesin function, and RNA transcript elongation and termination. Remodeler complexes are tailored both compositionally and mechanistically to perform particular chromatin functions.
引用
收藏
页码：185 / 190
页数：6
相关论文
共 50 条
[1]   H2A.Z is required for global chromatin integrity and for recruitment of RNA polymerase II under specific conditions [J].
Adam, M ;
Robert, F ;
Larochelle, M ;
Gaudreau, L .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (18) :6270-6279
[2]   Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PH05 and PH08 genes [J].
Adkins, MW ;
Howar, SR ;
Tyler, JK .
MOLECULAR CELL, 2004, 14 (05) :657-666
[3]   The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly [J].
Ahmad, K ;
Henikoff, S .
MOLECULAR CELL, 2002, 9 (06) :1191-1200
[4]   A role for chromatin remodeling in transcriptional termination by RNA polymerase II [J].
Alén, C ;
Kent, NA ;
Jones, HS ;
O'Sullivan, J ;
Aranda, A ;
Proudfoot, NJ .
MOLECULAR CELL, 2002, 10 (06) :1441-1452
[5]   The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion [J].
Baetz, KK ;
Krogan, NJ ;
Emili, A ;
Greenblatt, J ;
Hieter, P .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) :1232-1244
[6]   Global nucleosome occupancy in yeast [J].
Bernstein, BE ;
Liu, CL ;
Humphrey, EL ;
Perlstein, EO ;
Schreiber, SL .
GENOME BIOLOGY, 2004, 5 (09)
[7]   Removal of promoter nucleosomes by disassembly rather than sliding in vivo [J].
Boeger, H ;
Griesenbeck, J ;
Strattan, JS ;
Kornberg, RD .
MOLECULAR CELL, 2004, 14 (05) :667-673
[8]   Nucleosomes unfold completely at a transcriptionally active promoter [J].
Boeger, H ;
Griesenbeck, J ;
Strattan, JS ;
Kornberg, RD .
MOLECULAR CELL, 2003, 11 (06) :1587-1598
[9]   Activator-dependent regulation of transcriptional pausing on nucleosomal templates [J].
Brown, SA ;
Imbalzano, AN ;
Kingston, RE .
GENES & DEVELOPMENT, 1996, 10 (12) :1479-1490
[10]   Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities [J].
Bruno, M ;
Flaus, A ;
Stockdale, C ;
Rencurel, C ;
Ferreira, H ;
Owen-Hughes, T .
MOLECULAR CELL, 2003, 12 (06) :1599-1606
12345