Syk kinase as a treatment target for therapy in autoimmune diseases

被引：33
|
作者：
Kyttaris, Vasileios C. [1 ]
Tsokos, George C. [1 ]
机构：
[1] Harvard Univ, Sch Med, Harvard Inst Med, Beth Israel Deaconess Med Ctr,Div Rheumatol, Boston, MA 02115 USA
来源：
CLINICAL IMMUNOLOGY | 2007年 / 124卷 / 03期
关键词：
autoimmunity; rheumatoid arthritis; Syk kinase; Fc gamma receptor;
D O I：
10.1016/j.clim.2007.06.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Spleen tyrosine kinase (Syk) associates with a variety of immunoreceptors in myetoid and lymphoid cells. Syk initiates intracellular signaling once the receptor is engaged by its ligand. Blocking Syk may prove beneficial in interrupting the propagation of the abnormal immune response in both autoimmune and allergic diseases. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：235 / 237
页数：3
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