Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases

被引：31

作者：

Karali, Nilgun ^{[1
]}

Akdemir, Atilla ^{[2
]}

Goktas, Fusun ^{[1
]}

Elma, Pinar Eraslan ^{[1
]}

Angeli, Andrea ^{[3
]}

Kizilirmak, Merih ^{[1
]}

Supuran, Claudiu T. ^{[3
]}

机构：

[1] Istanbul Univ, Dept Pharmaceut Chem, Fac Pharm, TR-34116 Istanbul, Turkey

[2] Bezmialem Vakif Univ, Dept Pharmacol, Comp Aided Drug Discovery Lab, Fac Pharm, TR-34093 Istanbul, Turkey

[3] Univ Firenze, Sez Sci Farmaceut, Dept NEUROFARBA, I-50019 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2017年 / 25卷 / 14期

关键词：

Carbonic anhydrase; Isatin; 2-Indolinone; Docking; IN-VITRO ANTICANCER; ISATIN-BETA-THIOSEMICARBAZONES; MULTIDRUG-RESISTANT CELLS; ANTITUBERCULOSIS ACTIVITY; DERIVATIVES; ANALOGS; AGENTS; CYTOTOXICITY; COMPLEXES; LIGANDS;

D O I：

10.1016/j.bmc.2017.05.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human carbonic anhydrases IX and XII are upregulated in many tumors and form a novel target for new generation anticancer drugs. Here we report the synthesis of novel 2-indolinone derivatives with the sulfonamide group as a zinc binding moiety. Enzyme inhibition assays confirmed that the compounds showed selectivity against hCA IX and XII over the widely distributed off-targets hCA I and II. Molecular modelling studies were performed to suggest modes of binding for these compounds. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3714 / 3718

页数：5

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