Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

被引：34
作者：
Bermejo-Velasco, Daniel [1 ]
Nawale, Ganesh N. [1 ]
Oommen, Oommen P. [2 ,3 ]
Hilborn, Joens [1 ]
Varghese, Oommen P. [1 ]
机构：
[1] Uppsala Univ, Translat Chem Biol Lab, Div Polymer Chem, Dept Chem Angstrom, Uppsala, Sweden
[2] Tampere Univ Technol, Bioengn & Nanomed Lab, Fac Biomed Sci & Engn, Tampere 33720, Finland
[3] BioMediTech Inst, Tampere 33720, Finland
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 88期
关键词：
N-TERMINAL CYSTEINE; COPPER(I)-CATALYZED AZIDE-ALKYNE; SITE-SPECIFIC CONJUGATION; IN-VIVO; PROTEIN MODIFICATION; CHEMICAL-SYNTHESIS; BUILDING-BLOCKS; PEPTIDE; LIGATION; BIOCONJUGATION;
D O I：
10.1039/c8cc05405c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner.
引用
收藏
页码：12507 / 12510
页数：4
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