Pathologic Complete Response of Pancreatic Cancer following Neoadjuvant FOLFIRINOX Treatment in Hepatic Metastasized Pancreatic Cancer

被引：12

作者：

Luu, Andreas Minh ^{[1
]}

Hoehn, Philipp ^{[1
]}

Vogel, SinaRabea ^{[1
]}

Reinacher-Schick, Anke ^{[2
]}

Munding, Johanna ^{[3
]}

Uhl, Waldemar ^{[1
]}

Braumann, Chris ^{[1
]}

机构：

[1] Ruhr Univ Bochum, St Josef Hosp, Dept Gen & Visceral Surg, Bochum, Germany

[2] Ruhr Univ Bochum, St Josef Hosp, Dept Oncol, Bochum, Germany

[3] Ruhr Univ Bochum, Univ Hosp Bergmannsheil, Inst Pathol, Bochum, Germany

来源：

VISCERAL MEDICINE | 2019年 / 35卷 / 06期

关键词：

Pathologic complete response; ypT0; Pancreatic cancer; Hepatic metastases; FOLFIRINOX; RESECTION; OUTCOMES; THERAPY;

D O I：

10.1159/000497827

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: Pancreatic cancer is a lethal disease and often asymptomatic. Therefore, it is most often diagnosed at an advanced stage. The standard approach in a metastasized tumor stage is palliative chemotherapy. However, the prognosis remains extremely poor. Case Report: We present the case of a patient who was diagnosed with a cancer of the head of the pancreas with hepatic metastases. After receiving palliative intended chemotherapy with the FOLFIRINOX regimen, staging computed tomography revealed the disappearance of the liver metastases and local resectability of the pancreatic head tumor. The patient underwent an uneventful Whipple's procedure. Surprisingly, pathohistological investigation revealed a complete pathological response. Conclusion: Pathological complete response after FOLFIRINOX treatment in hepatic metastasized pancreatic cancer is extremely rare. It enables surgical resection and increases the survival rate significantly.

引用

页码：387 / 390

页数：4

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