One-Pot Synthesis of Benzene and Pyridine Derivatives via Copper-Catalyzed Coupling Reactions

被引：44
|
作者：
Han, Jianwei [1 ,2 ]
Guo, Xin [1 ,2 ]
Liu, Yafeng [1 ,2 ]
Fu, Yajie [1 ,2 ]
Yan, Rulong [1 ,2 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 15期
基金：
美国国家科学基金会;
关键词：
polysubstituted pyridine; copper-catalyzed; polysubstituted benzene; acetophenones; toluene derivatives; SUBSTITUTED PYRIDINES; POLYSUBSTITUTED PYRIDINES; SYMMETRICAL PYRIDINES; KETOXIME ACETATES; BOND-CLEAVAGE; CYCLIZATION; ALDEHYDES; ACTIVATION; AMINATION; ARYLATION;
D O I：
10.1002/adsc.201700053
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A highly efficient one-pot synthesis of polysubstituted pyridine has been achieved through copper-catalyzed oxidative sp(3) C-H coupling of acetophenones with toluene derivatives. Besides, the polysubstituted benzene was obtained through copper-catalyzed coupling of acetophenones. Both of the reactions exhibited a good functional group tolerance to produce a 2,4,6-triphenylpyridine or 1,3,5-triarylbenzene in high yields. Compared with previous methods, these transformations allow a highly flexible and efficient preparation of substituted pyridines and benzenes.
引用
收藏
页码：2676 / 2681
页数：6
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