Peptide-peptoid hybrids based on (1-11)-parathyroid hormone analogs

被引：4

作者：

Caporale, A. ^{[1
]}

Schievano, E. ^{[1
]}

Peggion, E. ^{[1
]}

机构：

[1] Univ Padua, Inst Biomol Chem, CNR, Dept Chem Sci, I-35131 Padua, Italy

来源：

JOURNAL OF PEPTIDE SCIENCE | 2010年 / 16卷 / 09期

关键词：

N-substituted glycine; peptidomimetics; PTH analogs; conformation; bioactivities; N-SUBSTITUTED GLYCINES; PARATHYROID-HORMONE; PTH(1-11) ANALOGS; IDENTIFICATION; DRUG; LIBRARY; DESIGN; MINIMIZATION; AGONISTS; SPECTRA;

D O I：

10.1002/psc.1265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2 (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor. Copyright (c) 2010 European Peptide Society and John Wiley & Sons, Ltd.

引用

页码：480 / 485

页数：6

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