Trinuclear Half-Sandwich RuII, RhIII and IrIII Polyester Organometallic Complexes: Synthesis and in vitro Evaluation as Antitumor Agents

被引：27

作者：

Burgoyne, Andrew R. ^{[1
]}

Makhubela, Banothile C. E. ^{[1
]}

Meyer, Mervin ^{[2
]}

Smith, Gregory S. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa

[2] Univ Western Cape, Dept Biotechnol, ZA-7535 Cape Town, South Africa

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 08期

基金：

新加坡国家研究基金会;

关键词：

Half-sandwich complexes; Bioorganometallic chemistry; Antitumor agents; Polyesters; ARENE RUTHENIUM COMPLEXES; DRUG-DELIVERY; MOLECULAR-STRUCTURE; ANTICANCER ACTIVITY; DENDRIMERS; IRIDIUM; ESTER; ELECTROCHEMISTRY; LIGANDS; RHODIUM;

D O I：

10.1002/ejic.201403192

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either 2-pyridinecarboxaldehyde or salicylaldehyde were used to synthesise bidentate trimeric ester ligands. The trimeric ester ligands were used to prepare a new series of trinuclear polyester organometallic complexes by using the dimeric precursors, [Ru((6)-p-iPrC(6)H(4)Me)Cl-2](2), [Rh(C5Me5)Cl-2](2) or [Ir(C5Me5)Cl-2](2). The Schiff base ligands act as bidentate donors to each metal. All compounds were characterised by NMR and IR spectroscopy, elemental analysis and EI/ESI mass spectrometry. Model mononuclear analogues were prepared, and the molecular structures of selected compounds were determined by single-crystal X-ray diffraction analysis. The mono- and trimeric ligands and the metal complexes were evaluated for inhibitory effects against the human ovarian cancer cell lines, A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant), and the model human skin fibroblast cell line, KMST-6.

引用

页码：1433 / 1444

页数：12

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