The microRNA pathway and cancer

被引：211

作者：

Kwak, Pieter Bas ^{[1
,2
]}

Iwasaki, Shintaro ^{[1
,2
]}

Tomari, Yukihide ^{[1
,2
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo, Japan

[2] Univ Tokyo, Dept Med Genome Sci, Bunkyo Ku, Tokyo, Japan

来源：

CANCER SCIENCE | 2010年 / 101卷 / 11期

基金：

日本学术振兴会;

关键词：

MESSENGER-RNA DEADENYLATION; MIRNA-MEDIATED REPRESSION; LET-7; MICRORNA; TRANSLATIONAL REPRESSION; NUCLEAR EXPORT; CAENORHABDITIS-ELEGANS; INITIATION; COMPLEX; PROTEIN; DICER;

D O I：

10.1111/j.1349-7006.2010.01683.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are similar to 22 nt long, non-coding RNAs that guide post-transcriptional gene silencing of their target genes and regulate diverse biological processes including cancer. miRNAs do not act alone, but require assembly into RNA-induced silencing complex (RISC). In this review, we summarize how miRNAs are produced, assembled into RISC, and regulate target mRNAs, and discuss how the miRNA pathway is involved in cancer. (Cancer Sci 2010; 101: 2309-2315).

引用

页码：2309 / 2315

页数：7

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