Crowded little caves:: Structure and function of caveolae

被引:148
作者
Schlegel, A
Volonté, D
Engelman, JA
Galbiati, F
Mehta, P
Zhang, XL
Scherer, PE
Lisanti, MP
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA
关键词
caveolae; caveolin proteins; signal transduction; oncogenes; cell transformation; tumor suppression;
D O I
10.1016/S0898-6568(98)00007-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Caveolae are small vesicular invaginations of the cell membrane. It is within this organelle that cells perform transcytosis, potocytosis and signal transduction. These "little caves" are composed of a mixture of lipids and proteins unlike those found in the plasma membrane proper. The chief structural proteins of caveolae are caveolins. To date, three caveolins (Cav-1, -2 and -3) with unique tissue distributions have been identified. Caveolins form a scaffold onto which many signalling molecules can assemble, to generate pre-assembled signalling complexes. In addition to concentrating these signal transducers within a distinct region of the plasma membrane, caveolin binding may functionally regulate the activation state of caveolae-associated signalling molecules. CELL SIGNAL 10;7:457-463, 1998. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:457 / 463
页数:7
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