Anti-androgenic activity of Myricae Cortex -: Isolation of active constituents from bark of Myrica rubra

被引：46

作者：

Matsuda, H

Yamazaki, M

Matsuo, K

Asanuma, Y

Kubo, M

机构：

[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

[2] Daiichi Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038234, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 03期

关键词：

Myrica rubra; testosterone; 5; alpha-reductase; anti-androgenic activity; hair regrowth;

D O I：

10.1248/bpb.24.259

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB, et Zucc., Myrieaceae) showed in vitro testosterone 5 alpha -reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.

引用

页码：259 / 263

页数：5

共 12 条

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[Anonymous], FRAGR J

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