Role of Glycosylation in Vascular Calcification

被引：25

作者：

Masbuchin, Ainun Nizar ^{[1
,2
]}

Rohman, Mohammad Saifur ^{[2
]}

Liu, Ping-Yen ^{[1
,3
]}

机构：

[1] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 70457, Taiwan

[2] Brawijaya Univ, Dept Cardiol & Vasc Med, Fac Med, Malang 65111, Indonesia

[3] Natl Cheng Kung Univ, Div Cardiol Internal Med, Natl Cheng Kung Univ Hosp, Coll Med, Tainan 70403, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期

关键词：

vascular calcification; medial calcification; O-glycosylation; N-glycosylation; proteoglycan; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY CALCIFICATION; FAMILIAL TUMORAL CALCINOSIS; O-GLCNAC MODIFICATION; GROWTH-FACTOR-BETA; FETUIN-A; LINKED GLYCOSYLATION; EXPRESSION; MECHANISMS; RUNX2;

D O I：

10.3390/ijms22189829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylation is an important step in post-translational protein modification. Altered glycosylation results in an abnormality that causes diseases such as malignancy and cardiovascular diseases. Recent emerging evidence highlights the importance of glycosylation in vascular calcification. Two major types of glycosylation, N-glycosylation and O-glycosylation, are involved in vascular calcification. Other glycosylation mechanisms, which polymerize the glycosaminoglycan (GAG) chain onto protein, resulting in proteoglycan (PG), also have an impact on vascular calcification. This paper discusses the role of glycosylation in vascular calcification.

引用

页数：15

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