Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells

被引：55
作者：
Plano, Daniel [1 ]
Sanmartin, Carmen [1 ]
Moreno, Esther [1 ]
Prior, Celia [2 ]
Calvo, Alfonso [2 ]
Palop, Juan Antonio [1 ]
机构：
[1] Univ Navarra, Dept Quim Organ & Farmaceut, Secc Sintesis, E-31008 Pamplona, Spain
[2] Univ Navarra, CIMA, Ctr Appl Med Res, Div Oncol, E-31008 Pamplona, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期
关键词：
organoselenium; cytotoxics; prostate;
D O I：
10.1016/j.bmcl.2007.10.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC50 = 1.85 mu M) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6853 / 6859
页数：7
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