Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae

被引：43

作者：

Trees, DL

Sandul, AL

Whittington, WL

Knapp, JS

机构：

[1] Ctr Dis Control & Prevent, Bacterial STD Branch, Div AIDS STD TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Univ Washington, Neisseria Reference Lab, Dept Med, Seattle, WA 98195 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 08期

关键词：

D O I：

10.1128/AAC.42.8.2103

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87-->Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 mu g/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116-->Leu; MIC, 1.0 mu g/ml).

引用

页码：2103 / 2105

页数：3

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