Two New Anti-Tobacco Mosaic Virus Alkaloids from the Whole Plants of Thalictrum microgynum

被引：3

作者：

Wu, Yu-Ping ^{[1
,2
,3
]}

Lin, Zhong-Long ^{[1
]}

Zhao, Gao-Kun ^{[1
]}

Zhou, Min ^{[2
,3
]}

Yao, Heng ^{[1
]}

Zhang, Guang-Hai ^{[1
]}

Li, Wei ^{[1
]}

Yang, Guang-Yu ^{[2
,3
]}

Li, Yin-Ke ^{[2
,3
]}

Hu, Qiu-Fen ^{[2
,3
]}

Kong, Guang-Hui ^{[1
]}

机构：

[1] Yunnan Acad Tobacco Agr Sci, Kunming 650031, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China

[3] Yunnan Minzu Univ, Minist Educ, Kunming 650031, Yunnan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Thalictrum microgynum; alkaloids; anti-tobacco mosaic virus (anti-TMV) activity; CONSTITUENTS;

D O I：

10.1007/s10600-022-03771-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new (1 and 2), together with four known (3-6) alkaloids were isolated from the whole plants of Thalictrum microgynum. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results indicated that compounds 2-4 showed high anti-TMV activity with inhibition rates of 34.8, 42.1, and 35.2% at a concentration of 20 mu M, respectively. These rates were higher than that of ningnanmycin, a positive control. Compounds 1, 5, and 6 also showed potential anti-TMV activity with inhibition rates of 26.7, 24.8, and 28.2%.

引用

页码：699 / 703

页数：5

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