Cerebral thrombotic microangiopathy and antiphospholipid antibodies in Aicardi-Goutieres syndrome report of two sisters

被引：37
作者：
Rasmussen, M [1 ]
Skullerud, K
Bakke, SJ
Lebon, P
Jahnsen, FL
机构：
[1] Natl Hosp Norway, Dept Pediat, N-0027 Oslo, Norway
[2] Univ Oslo, Rikshosp, Dept Pathol, N-0027 Oslo, Norway
[3] Univ Oslo, Rikshosp, Inst Pathol, N-0027 Oslo, Norway
[4] Natl Hosp Norway, Dept Radiol, N-0027 Oslo, Norway
[5] Univ Paris 05, Hop St Vincent de Paul, Serv Virol, Paris, France
来源：
NEUROPEDIATRICS | 2005年 / 36卷 / 01期
关键词：
Aicardi-Goutieres syndrome; thrombotic microangiopathy; antiphospholipid antibodies; systemic lupus erythematosus; interferon;
D O I：
10.1055/s-2004-830532
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cerebral thrombotic microangiopathy was found at autopsy in one of two sisters with Aicardi-Goutieres syndrome, whereas the other revealed increased serum levels of anticardiolipin IgG antibodies (measured only in the living sister); both typical features of systemic lupus erythematosus. These findings add support to the suggestion that Aicardi-Goutieres syndrome and systemic lupus erythematosus are closely related disorders in which dysregulated production of interferon-alpha might play a crucial role.
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页码：40 / 44
页数：5
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