Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells

被引：7
作者：
Hwang, Gi-Wook [1 ]
Ryoke, Katsunori [1 ]
Takahashi, Tsutomu [1 ]
Naganuma, Akira [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Mol & Biochem Toxicol, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2010年 / 35卷 / 06期
基金：
日本学术振兴会;
关键词：
Methylmercury; Homeobox protein; HOXB13; Transcription factor; EXPRESSION; TOXICITY; CANCER;
D O I：
10.2131/jts.35.941
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Methylmercury is an environmental pollutant that causes severe central nervous system disorders. We searched for transcription factors involved in the development of methylmercury toxicity and found that the decreased expression of a homeobox protein, HOXB13, in HEK293 cells conferred strong resistance to methylmercury.
引用
收藏
页码：941 / 944
页数：4
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