Melanocortin system and eating disorders

被引：27

作者：

Adan, RAH ^{[1
]}

Hillebrand, JJG ^{[1
]}

De Rijke, C ^{[1
]}

Nijenhuis, W ^{[1
]}

Vink, T ^{[1
]}

Garner, KM ^{[1
]}

Kas, MJH ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Dept Pharmacol & Anat, Rudolf Magnus Inst Neurosci, NL-3584 CG Utrecht, Netherlands

来源：

MELANOCORTIN SYSTEM | 2003年 / 994卷

关键词：

activity-based anorexia; anorexia nervosa; inverse agonist; agouti-related peptide (AgRP); stress; melanocortin (MC);

D O I：

10.1111/j.1749-6632.2003.tb03189.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The melanocortin (MC) system is involved in the regulation of energy balance and in the development of obesity. Here we briefly review why we became interested in investigating whether the MC system-more particularly, the increased activity of the MC system-is also involved in disorders of negative energy balance. We provide evidence that suppression of increased MC receptor activity by treatment with the inverse agonist agouti-related peptide (AgRP) (83-132) rescues rats exposed to an animal model known as activity-based anorexia. Furthermore, we found a polymorphism, Ala67Thr AgRP, that was observed more frequently in anorexia nervosa.

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收藏

页码：267 / 274

页数：8

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