LFA-1 in T cell priming, differentiation, and effector functions

被引：58

作者：

Gerard, Audrey ^{[1
]}

Cope, Andrew P. ^{[2
]}

Kemper, Claudia ^{[3
,4
]}

Alon, Ronen ^{[5
]}

Kochl, Robert ^{[6
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England

[2] Kings Coll London, Ctr Inflammat Biol & Canc Immunol, London, England

[3] NHLBI, NIH, CIRS, Bldg 10, Bethesda, MD 20892 USA

[4] Univ Lubeck, Inst System Inflammat Res, Lubeck, Germany

[5] Weizmann Inst Sci, Rehovot, Israel

[6] Kings Coll London, Peter Gorer Dept Immunobiol, London, England

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 以色列科学基金会;

关键词：

ANTIGEN-PRESENTING CELLS; COFACTOR PROTEIN CD46; DENDRITIC CELLS; LYMPH-NODES; IN-VIVO; IMMUNOLOGICAL SYNAPSE; ADHESION MOLECULE; IMMUNE-RESPONSE; ACTIVATION; COMPLEMENT;

D O I：

10.1016/j.it.2021.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell-T cell (T-T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.

引用

页码：706 / 722

页数：17

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