A lipidomic view of SARS-CoV-2

被引：7

作者：

Ebrahimi, Kourosh H. ^{[1
]}

McCullagh, James S. O. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford, England

来源：

BIOSCIENCE REPORTS | 2021年 / 41卷 / 08期

关键词：

COMMENSAL BACTERIA; METABOLISM; LIPOPROTEINS; CHOLESTEROL; INFECTION;

D O I：

10.1042/BSR20210953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which started in late 2019, has caused huge social and economic losses. A growing number of investigators are focusing on understanding the interaction of SARS-CoV-2 with host cellular processes to find therapeutic approaches. New data suggest that lipid metabolism may play a significant role in regulating the response of immune cells like macrophages to viral infection, thereby affecting the outcome of the disease. Therefore, understanding the role of lipid metabolism could help develop new therapeutic approaches to mitigate the social and economic cost of coronavirus disease 2019 (COVID-19).

引用

页数：7

共 40 条

[21] Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in 21 industrialized countries [J].

Kontis, Vasilis ;

Bennett, James E. ;

Rashid, Theo ;

Parks, Robbie M. ;

Pearson-Stuttard, Jonathan ;

Guillot, Michel ;

Asaria, Perviz ;

Zhou, Bin ;

Battaglini, Marco ;

Corsetti, Gianni ;

McKee, Martin ;

Di Cesare, Mariachiara ;

Mathers, Colin D. ;

Ezzati, Majid .

NATURE MEDICINE, 2020, 26 (12) :1919-1928

[22] Richness of human gut microbiome correlates with metabolic markers [J].

Le Chatelier, Emmanuelle ;

Nielsen, Trine ;

Qin, Junjie ;

Prifti, Edi ;

Hildebrand, Falk ;

Falony, Gwen ;

Almeida, Mathieu ;

Arumugam, Manimozhiyan ;

Batto, Jean-Michel ;

Kennedy, Sean ;

Leonard, Pierre ;

Li, Junhua ;

Burgdorf, Kristoffer ;

Grarup, Niels ;

Jorgensen, Torben ;

Brandslund, Ivan ;

Nielsen, Henrik Bjorn ;

Juncker, Agnieszka S. ;

Bertalan, Marcelo ;

Levenez, Florence ;

Pons, Nicolas ;

Rasmussen, Simon ;

Sunagawa, Shinichi ;

Tap, Julien ;

Tims, Sebastian ;

Zoetendal, Erwin G. ;

Brunak, Soren ;

Clement, Karine ;

Dore, Joel ;

Kleerebezem, Michiel ;

Kristiansen, Karsten ;

Renault, Pierre ;

Sicheritz-Ponten, Thomas ;

de Vos, Willem M. ;

Zucker, Jean-Daniel ;

Raes, Jeroen ;

Hansen, Torben ;

Bork, Peer ;

Wang, Jun ;

Ehrlich, S. Dusko ;

Pedersen, Oluf .

NATURE, 2013, 500 (7464) :541-+

[23] COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm [J].

Lee, Wonhwa ;

Ahn, June Hong ;

Park, Hee Ho ;

Kim, Hong Nam ;

Kim, Hyelim ;

Yoo, Youngbum ;

Shin, Hyosoo ;

Hong, Kyung Soo ;

Jang, Jong Geol ;

Park, Chun Gwon ;

Choi, Eun Young ;

Bae, Jong-Sup ;

Seo, Young-Kyo .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 5 (01)

[24] Lipid metabolism changes in patients with severe COVID-19 [J].

Li, Yi ;

Zhang, Yan ;

Lu, Rongli ;

Dai, Minhui ;

Shen, Minxue ;

Zhang, Jianchu ;

Cui, Yanhui ;

Liu, Ben ;

Lin, Fengyu ;

Chen, Lingli ;

Han, Duoduo ;

Fan, Yifei ;

Zeng, Yanjun ;

Li, Wen ;

Li, Sha ;

Chen, Xiang ;

Li, Haitao ;

Pan, Pinhua .

CLINICA CHIMICA ACTA, 2021, 517 :66-73

[25] How does SARS-CoV-2 cause COVID-19? [J].

Matheson, Nicholas J. ;

Lehner, Paul J. .

SCIENCE, 2020, 369 (6503) :510-511

[26]

Murphy AJ, 2013, ISRN PHYSL, V2013, P1, DOI [10.1155/2013/186365, DOI 10.1155/2013/186365]

[27]

Nassir Fatiha, 2015, Gastroenterol Hepatol (N Y), V11, P167

[28] The inflammatory profile and liver damage of a sucrose-rich diet in mice [J].

Oliveira, Liliane Soares C. ;

Santos, Daiane A. ;

Barbosa-da-Silva, Sandra ;

Mandarim-de-Lacerda, Carlos A. ;

Aguila, Marcia B. .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2014, 25 (02) :193-200

[29] ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection? [J].

Pagliari, Francesca ;

Marafioti, Maria Grazia ;

Genard, Geraldine ;

Candeloro, Patrizio ;

Viglietto, Giuseppe ;

Seco, Joao ;

Tirinato, Luca .

FRONTIERS IN MOLECULAR BIOSCIENCES, 2020, 7

[30] Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link? [J].

Rebello, Candida J. ;

Kirwan, John P. ;

Greenway, Frank L. .

INTERNATIONAL JOURNAL OF OBESITY, 2020, 44 (09) :1810-1817

← 1 2 3 4 →