The respiratory microbiome of HIV-infected individuals

被引：18

作者：

Lawani, M. B. ^{[1
]}

Morris, A. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

来源：

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2016年 / 14卷 / 08期

关键词：

HIV infection; lung microbiome; mycobiome; virome; pulmonary disease; bronchoalveolar lavage; OBSTRUCTIVE PULMONARY-DISEASE; INFLUENZA-A VIRUS; CYSTIC-FIBROSIS; BRONCHOALVEOLAR LAVAGE; LUNG MICROBIOME; PNEUMOCYSTIS COLONIZATION; BACTERIAL MICROBIOME; METAGENOMIC ANALYSIS; TROPHERYMA-WHIPPLEI; T-CELLS;

D O I：

10.1080/14787210.2016.1206469

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: The respiratory tract is constantly exposed to various environmental and endogenous microbes; however, unlike other similar mucosal surfaces, there has been limited investigation of the microbiome of the respiratory tract.Areas covered: In this review, we summarize the current state of knowledge of the bacterial, fungal, and viral respiratory microbiomes during HIV infection and how the microbiome might relate to HIV-associated lung disease.Expert commentary: HIV infection is associated with alterations in the respiratory microbiome. The clinical implications of lung microbial dysbiosis are however currently unknown. Mechanistic studies are needed to establish causality between shifts in the respiratory microbiome and pulmonary complications in HIV-infected individuals.

引用

页码：719 / 729

页数：11

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