HIV pathogenesis: The first cut is the deepest

被引:73
作者
Picker, LJ [1 ]
Watkins, DI
机构
[1] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Beaverton, OR 97006 USA
[2] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
[3] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53706 USA
[4] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53706 USA
关键词
D O I
10.1038/ni0505-430
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
HIV pathogenesis is thought of as a chronic infection involving slow degradation of immunity that ultimately leads to AIDS. This scenario, however, could reflect the decay of an immune system mortally wounded during acute HIV infection.
引用
收藏
页码:430 / 432
页数:4
相关论文
共 12 条
[1]   CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].
Brenchley, JM ;
Schacker, TW ;
Ruff, LE ;
Price, DA ;
Taylor, JH ;
Beilman, GJ ;
Nguyen, PL ;
Khoruts, A ;
Larson, M ;
Haase, AT ;
Douek, DC .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :749-759
[2]   T cell dynamics in HIV-1 infection [J].
Douek, DC ;
Picker, LJ ;
Koup, RA .
ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :265-304
[3]   HIV preferentially infects HIV-specific CD4+ T cells [J].
Douek, DC ;
Brenchley, JM ;
Betts, MR ;
Ambrozak, DR ;
Hill, BJ ;
Okamoto, Y ;
Casazza, JP ;
Kuruppu, J ;
Kuntsman, K ;
Wolinsky, S ;
Grossman, Z ;
Dybul, M ;
Oxenius, A ;
Price, DA ;
Connors, M ;
Koup, RA .
NATURE, 2002, 417 (6884) :95-98
[4]  
MATTAPALLIL JJ, NATURE
[5]   The dynamics of CD4+ T-cell depletion in HIV disease [J].
McCune, JM .
NATURE, 2001, 410 (6831) :974-979
[6]   Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract [J].
Mehandru, S ;
Poles, MA ;
Tenner-Racz, K ;
Horowitz, A ;
Hurley, A ;
Hogan, C ;
Boden, D ;
Racz, P ;
Markowitz, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :761-770
[7]   Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection [J].
Picker, LJ ;
Hagen, SI ;
Lum, R ;
Reed-Inderbitzin, EF ;
Daly, LM ;
Sylwester, AW ;
Walker, JM ;
Siess, DC ;
Piatak, M ;
Wang, CX ;
Allison, DB ;
Maino, VC ;
Lifson, JD ;
Kodama, T ;
Axthelm, MK .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (10) :1299-1314
[8]   Viral load and heterosexual transmission of human immunodeficiency virus type 1 [J].
Quinn, TC ;
Wawer, MJ ;
Sewankambo, N ;
Serwadda, D ;
Li, CJ ;
Wabwire-Mangen, F ;
Meehan, MO ;
Lutalo, T ;
Gray, RH .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (13) :921-929
[9]   Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts [J].
Silvestri, G ;
Fedanov, A ;
Germon, S ;
Kozyr, N ;
Kaiser, WJ ;
Garber, DA ;
McClure, H ;
Feinberg, MB ;
Staprans, SI .
JOURNAL OF VIROLOGY, 2005, 79 (07) :4043-4054
[10]   Decreased CCR5 expression on CD4+ T cells of SIV-infected sooty Mangabeys [J].
Veazey, R ;
Ling, BH ;
Pandrea, I ;
McClure, H ;
Lackner, A ;
Marx, P .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2003, 19 (03) :227-233