Systemic Delivery and Biodistribution of Cisplatin in Vivo

被引：29
作者：
Chu, Yu-Hsuan [1 ]
Sibrian-Vazquez, Martha [1 ]
Escobedo, Jorge O. [1 ]
Phillips, Amanda R. [2 ]
Dickey, D. Thomas [2 ]
Wang, Qi [2 ]
Ralle, Martina [3 ]
Steyger, Peter S. [2 ]
Strongin, Robert M. [1 ]
机构：
[1] Portland State Univ, Dept Chem, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA
[3] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97239 USA
来源：
MOLECULAR PHARMACEUTICS | 2016年 / 13卷 / 08期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
cisplatin; Texas Red; conjugate; ototoxicity; tracer; PLATINUM CHEMOTHERAPY; STRIA VASCULARIS; BRAIN-TUMORS; HAIR-CELLS; GUINEA-PIG; PHARMACOKINETICS; NEPHROTOXICITY; CANCER; OTOTOXICITY; GENTAMICIN;
D O I：
10.1021/acs.molpharmaceut.6b00240
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects; a new drug fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics. and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.
引用
收藏
页码：2677 / 2682
页数：6
相关论文
共 34 条
  • [1] Design, synthesis, and evaluation of cisplatin-containing EGFR targeting bioconjugates as potential therapeutic agents for brain tumors
    Barth, Rolf F.
    Wu, Gong
    Meisen, W. Hans
    Nakkula, Robin J.
    Yang, Weilian
    Huo, Tianyao
    Kellough, David A.
    Kaumaya, Pravin
    Turro, Claudia
    Agius, Lawrence M.
    Kaur, Balveen
    [J]. ONCOTARGETS AND THERAPY, 2016, 9 : 2769 - 2781
  • [2] Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment
    Callari, Manuela
    Aldrich-Wright, Janice R.
    de Souza, Paul L.
    Stenzel, Martina H.
    [J]. PROGRESS IN POLYMER SCIENCE, 2014, 39 (09) : 1614 - 1643
  • [3] Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions
    Ciarimboli, Giuliano
    Deuster, Dirk
    Knief, Arne
    Sperling, Michael
    Holtkamp, Michael
    Edemir, Bayram
    Pavenstaedt, Hermann
    Lanvers-Kaminsky, Claudia
    Zehnhoff-Dinnesen, Antoinette Am
    Schinkel, Alfred H.
    Koepsell, Hermann
    Juergens, Heribert
    Schlatter, Eberhard
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (03) : 1169 - 1180
  • [4] Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
    Dai, CF
    Mangiardi, D
    Cotanche, DA
    Steyger, PS
    [J]. HEARING RESEARCH, 2006, 213 (1-2) : 64 - 78
  • [5] A systemic gentamicin pathway across the stria vascularis
    Dai, Chun Fu
    Steyger, Peter S.
    [J]. HEARING RESEARCH, 2008, 235 (1-2) : 114 - 124
  • [6] AMINOGLYCOSIDE ANTIBIOTICS IMPAIR CALCIUM ENTRY BUT NOT VIABILITY AND MOTILITY IN ISOLATED COCHLEAR OUTER HAIR-CELLS
    DULON, D
    ZAJIC, G
    ARAN, JM
    SCHACHT, J
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 24 (02) : 338 - 346
  • [7] Curing metastatic testicular cancer
    Einhorn, LH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) : 4592 - 4595
  • [8] Ototoxicity, nephrotoxicity and pharmacokinetics of cisplatin and its monohydrated complex in the guinea pig
    Ekborn, A
    Lindberg, A
    Laurell, G
    Wallin, I
    Eksborg, S
    Ehrsson, H
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2003, 51 (01) : 36 - 42
  • [9] GINOS JZ, 1987, J NUCL MED, V28, P1844
  • [10] HALL KS, 1991, DRUG METAB DISPOS, V19, P725
1234