Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520

被引：8

作者：

Zhang, Huaran ^{[1
,2
,3
]}

Chen, Yingying ^{[1
]}

Li, Yanqing ^{[1
,2
,3
]}

Song, Yongxiang ^{[1
]}

Ma, Junying ^{[1
,2
,3
]}

Ju, Jianhua ^{[1
,2
,3
]}

机构：

[1] Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China

[2] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, 164 West Xingang Rd, Guangzhou 510301, Peoples R China

[3] Univ Chinese Acad Sci, Coll Oceanol, Qingdao 266400, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

polyketide; biosynthesis; Streptomyces; hydrothermal vent; deep sea; SALINOMYCIN BIOSYNTHESIS; IDENTIFICATION; HOPANOIDS; MECHANISM;

D O I：

10.3390/md20060393

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Streptomyces sp. SCSIO ZS0520 is a deep-sea hydrothermal vent-derived actinomycete. Our previous metabolism investigation showed that Streptomyces sp. SCSIO ZS0520 is a producer of cytotoxic actinopyrones. Here, another four types of secondary metabolites were identified, including six salinomycin isomers (2-7), the macrolide elaiophylin (8), the triterpene N-acetyl-aminobacteriohopanetriol (9), and the pyrone minipyrone (10). Among them, compounds 2-6 and 10 are new compounds. To understand the biosynthetic pathway of these compounds, a bioinformatic analysis of the whole genome was carried out, which identified 34 secondary metabolite biosynthetic gene clusters. Next, the biosynthetic pathways responsive to four types of products were deduced on the basis of gene function predictions and structure information. Taken together, these findings prove the metabolite potential of ZS0520 and lay the foundations to solve the remaining biosynthetic issues in four types of marine natural products.

引用

页数：12

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