Cyanine dye conjugates as probes for live cell imaging

被引：75
作者：
Carreon, Jay R.
Stewart, Kelly M.
Mahon, Kerry P., Jr.
Shin, Stephanie
Kelley, Shana O. [1 ]
机构：
[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
[2] Boston Coll, Eugene F Merkert Chem Ctr, Chestnut Hill, MA 02467 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 18期
基金：
美国国家科学基金会;
关键词：
peptide conjugate; fluorescence imaging; cellular imaging; dyes;
D O I：
10.1016/j.bmcl.2007.06.097
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：5182 / 5185
页数：4
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