Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

被引：80

作者：

Winklewski, Pawel J. ^{[1
]}

Radkowski, Marek ^{[2
]}

Demkow, Urszula ^{[3
]}

机构：

[1] Med Univ Gdansk, Inst Human Physiol, PL-80210 Gdansk, Poland

[2] Med Univ Warsaw, Dept Immunopathol Infect & Parasit Dis, Warsaw, Poland

[3] Med Univ Warsaw, Dept Lab Diagnost & Clin Immunol Dev Age, Warsaw, Poland

来源：

JOURNAL OF NEUROINFLAMMATION | 2014年 / 11卷

关键词：

Stroke; Brain injury; Immune response; Sympathetic nervous system; Lung injury; Pneumonia; COMMUNITY-ACQUIRED PNEUMONIA; PITUITARY-ADRENAL AXIS; TRAUMATIC BRAIN-INJURY; ACUTE LUNG INJURY; CEREBRAL-ISCHEMIA; T-LYMPHOCYTES; NERVOUS-SYSTEM; SUBARACHNOID HEMORRHAGE; IMMUNE-SYSTEM; UP-REGULATION;

D O I：

10.1186/s12974-014-0213-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection.

引用

页数：8

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