Role of G Protein-coupled Orphan Receptors in Intestinal Inflammation: Novel Targets in Inflammatory Bowel Diseases

被引：10

作者：

Wasilewski, Andrzej ^{[1
]}

Storr, Martin ^{[2
]}

Zielinska, Marta ^{[1
]}

Fichna, Jakub ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Biochem, Fac Med, PL-92215 Lodz, Poland

[2] Univ Munich, Dept Med, Div Gastroenterol, Munich, Germany

来源：

INFLAMMATORY BOWEL DISEASES | 2015年 / 21卷 / 03期

关键词：

Crohn's disease; deorphanized GPCRs; experimental colitis; GPR ligands; ulcerative colitis; GROWTH-FACTOR RECEPTOR; BREAST-CANCER CELLS; CHAIN FATTY-ACIDS; ESTROGEN-RECEPTOR; MEMBRANE-RECEPTOR; CANNABINOID RECEPTOR; HUMAN GENOME; GASTROINTESTINAL-TRACT; CARDIOVASCULAR-SYSTEM; PHYLOGENETIC ANALYSIS;

D O I：

10.1097/MIB.0000000000000258

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A large number of proteins were classified into the family of G protein-coupled receptors (GPCRs). Based on their characteristic serpentine domain, they are called 7 TM receptors. Presently, their ligands and physiological functions remain unknown. In this review, we summarize what is known on these receptors and discuss the potential use of these orphan GPCRs (GPRs) in the induction or maintenance of remission in inflammatory bowel diseases. We focus on GPRs 30, 41, 43, 55, 119, and 120, where scientific evidence supports a potential role in intestinal inflammation.

引用

页码：666 / 673

页数：8

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