Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells

被引:9
作者
Geng, Hai-tao [1 ]
Cao, Rui-juan [1 ]
Cheng, Lei [2 ]
Liu, Chun-yuan [2 ]
机构
[1] Binzhou Med Univ Hosp, Dept Oncol, Binzhou, Shandong, Peoples R China
[2] Binzhou Med Univ Hosp, Dept Gen Surg, 661 Yellow River Rd, Binzhou 256603, Shandong, Peoples R China
关键词
Hepatocyte cell adhesion molecule (hepaCAM); Proliferation; Migration; Invasion; Colorectal cancer (CRC); BLADDER-CANCER; CATENIN; PROGRESSION; INTEGRINS; BREAST; LUNG;
D O I
10.3727/096504016X14813914187138
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin super family. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers investigated its biological function in the tumorigenesis of various cancers. However, what kind of role hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC tumor growth and metastasis in vivo. We also demonstrated that overexpression of hepaCAM reduced the protein expression levels of beta-catenin, cyclin D1, and c-Myc, indicating its inhibitory effect on the Wnt/beta-catenin signaling pathway. In conclusion, our study results suggest hepaCAM as a promising therapeutic target for CRC and provide a better understanding for the molecular basis of CRC progression.
引用
收藏
页码:1039 / 1046
页数:8
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