Probing and modulating the interactions of the DNAzyme with DNA-functionalized nanoparticles

被引：19

作者：

Hu, Yuqiang ^{[1
]}

Zhang, Zhen ^{[1
]}

Zhang, Wei ^{[2
,3
]}

Hu, Minghao ^{[1
]}

Xiao, Xianjin ^{[2
]}

Wu, Tongbo ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Reprod Hlth, Ctr Reprod Med, Wuhan 430030, Peoples R China

[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynaecol, Wuhan 430022, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2022年 / 33卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Gold nanoparticles; DNAzyme; Interface interaction; Rate difference; Human apuriniciapyrimidinic endonuclease 1; GOLD NANOPARTICLES; SURFACE SCIENCE; STRANDED-DNA; ADSORPTION; MONOLAYERS; BINDING; BASES;

D O I：

10.1016/j.cclet.2021.09.039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-functionalized gold nanoparticles are one of the most versatile bionanomaterials for biomedical and clinical diagnosis. Herein, we discovered that the performance of DNAzyme cleaving the substrate is highly related to its length. This intriguing phenomenon only appears at the interfaces of DNA-functionalized gold nanoparticles. We systematically investigated the causes of this phenomenon. We conjectured that the DNAzyme with extended nucleotides that do not match its substrate strand is vulnerable to non-specific adsorption, electrostatic repulsion, and steric hindrance. Based on our improved understanding of this phenomenon, we have successfully developed a highly sensitive and specific amplifiable biosensor to detect human apurinic/apyrimidinic endonuclease 1. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页码：3026 / 3030

页数：5

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