Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda

被引：62
|
作者：
Nsobya, Samuel L.
Dokomajilar, Christian
Joloba, Moses
Dorsey, Grant
Rosenthal, Philip J.
机构：
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[2] Makerere Univ, Dept Med, Kampala, Uganda
[3] Makerere Univ, Dept Microbiol, Kampala, Uganda
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期
关键词：
D O I：
10.1128/AAC.00012-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.
引用
收藏
页码：3023 / 3025
页数：3
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